Evidence Grades [May 2021]
 

The following explains the criteria used to determine the Grading of VCI Recommendations.
Both the grading criteria and the available evidence are regularly reviewed and updated.

 

Ungraded Information

  • Expert Opinion: TBD

  • PK/PD:  TBD

  • Toxicology: TBD

  • Case Reports: TBD

  • Review Information: TBD

  • Controlled Trials: TBD

  • Systematic Reviews: TBD

No Evidence

  • Expert Opinion: Yes

  • PK/PD:  No

  • Toxicology: No

  • Case Reports: No

  • Review Information: No

  • Controlled Trials: No

  • Systematic Reviews: No

Robust Evidence

  • Expert Opinion: Yes

  • PK/PD:  Yes

  • Toxicology: Yes

  • Case Reports: Yes 

  • Review Information: Maybe

  • Controlled Trials: Yes

  • Systematic Reviews: Yes

Strong Evidence

  • Expert Opinion: Yes

  • PK/PD:  Yes

  • Toxicology: Yes

  • Case Reports: Yes 

  • Review Information: Maybe

  • Controlled Trials: Yes

  • Systematic Reviews: Maybe

Good Evidence

  • Expert Opinion: Yes

  • PK/PD:  Yes

  • Toxicology: Yes

  • Case Reports: Yes 

  • Review Information: Maybe

  • Controlled Trials: Yes

  • Systematic Reviews: Probably Not

Weak Evidence

  • Expert Opinion: Yes

  • PK/PD:  Yes

  • Toxicology: Maybe

  • Case Reports: Yes 

  • Review Information: Maybe

  • Controlled Trials: No

  • Systematic Reviews: No

Inadequate Evidence

  • Expert Opinion: Yes

  • PK/PD:  No

  • Toxicology: Maybe

  • Case Reports: Yes 

  • Review Information: Maybe

  • Controlled Trials: No

  • Systematic Reviews: No